Hepatoprotective Effect of Pomegranate (Punica granatum L) Peels powder against Carbon Tetrachloride (CCl4)- Induced Hepatotoxicity in Rats

نوع المستند : مقالات علمیة محکمة

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Background: Carbon tetrachloride (CCL4) is a colorless, volatile nonflammable liquid, a haloalkane and inhalation of its vapors can cause degeneration of the liver, kidneys and other organs through the generation of reactive oxidative stress. Pomegranate (Punica granatum L) peel, a plant by-product has been demonstrated to be a rich source of bioactive antioxidants mainly polyphenols which can inhibit and control hepatic injury with high efficacy and low toxicity.
Aim of woker: This study aimed to investigate the hepatoprotective impact of pomegranate peel powder (POP) on the hepatic toxicity caused by carbon tetrachloride.
Methods: Male albino rats (n=30) were divided into 5 main groups (6 each). as follows: Group (1): Negative group control fed in basal diet, Group (2): used as the positive control group (+ve) and fed on basal diet. Groups (3, 4 and 5) fed on a basal diet with POP at levels of 2, 4 and 6 g/kg/diet/day, respectively. After, 29 days of the experiment, groups (2-5) were injected intraperitoneal with CCL4 (2 ml/b.w/rats to induce hepatic and other possible side effects as the renal disorders in rats, after 24 hours, rats were sacrificed and blood samples collected then centrifuged. Serum was kept frozen at - 20°C until analysis.

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