Studying Protective Effects of Aqueous Extract of Cinnamon Stem Bark and Stevia Leaves and Their Combination on Gentamicin-Induced Nephrotoxicity in Rats دراسة التأثيرات الواقية للمستخلص المائي للحاء جذوع القرفة وأوراق الاستيفيا وخليطهما على السمية الکلوية التي يسببها الجنتاميسين في الفئران

نوع المستند : مقالات علمیة محکمة

المؤلف

قسم التغذية وعلوم الاطعمة - کلية الاقتصاد المنزلي - جامعة حلوان

المستخلص

The principle aim of the present study was to assess the potential protective effect of aqueous extract (AE) of cinnamon stem bark (CSB) and stevia leaves (SL); and their combination against GM-induced nephrotoxicity in rats. Rats were grouped into five rats each in five groups. Group one kept as healthy control group; the other four groups were intraperitoneal injected with 100 mg/kg b.wt of GM for 10 days to induce nephrotoxicity. Rats of groups 3, 4 and 5 were administered daily 200 mg/kg of b.wt of AE of CSB and SL; and their combination, respectively. GM significantly (P<0.05) induced an elevation in relative weight of liver and kidney; serum biochemical markers of liver and kidney functions; and imbalance in oxidative parameters of kidney tissues, as well as morphological changes in the kidney, along with decreased body weight and total of serum albumin and protein levels. Co-administration AE of CSB or SL or their combination significantly ameliorates all of the tested parameters; and histopathological changes and the activities of antioxidant enzymes in kidney tissues were reconditioned. CSB or CSB + SL ameliorates all of the parameters more than that of SL. Finally, the present work demonstrated that AE of CSB and SL, or CSB + SL ameliorate the changes in liver or kidney functions and oxidative markers in the kidney induced by GM in rats. Thus, they can be used be used in reducing GM-induced nephrotoxicity.

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