Effect of Cloves (Syzygium Aromaticum) on Serum Biomarkers of Some Common Complications and Oxidative Stress on Alloxan-Induced Diabetic Rats

نوع المستند : مقالات علمیة محکمة

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كلية التربية النوعية جامعة المنصورة

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Objectives: This research aimed to find out the potential effect of cloves (Syzygium aromaticum) on hyperglycemia, hyperlipidemia, hepato-renal disorders and oxidative stress as the known complications related to diabetes. Materials and Methods: forty male rats were divided into 5 groups (n=8), including the healthy control group (NC) and four diabetic groups. Alloxan- monohydrate (BDH) was used for prompting diabetes (100mg/kg b.w.). Rats with diabetes were put into a control group (DC), diabetic treated with clove oil (200mg\kg) (G3), clove extract (200mg\kg) (G4) and clove powder (20g\kg) (G5). After 4 weeks of the treatment, the blood samples were taken for measuring the fasting blood glucose, insulin, lipid profiles, liver and kidney functions and some antioxidant/oxidative stress markers. Results: The therapeutic groups (clove oil, extract and powder) statistics had low levels of fasting blood sugar, total cholesterol, LDL-c, VLDL-c, triglycerides, AST, ALT, urea, uric acid, creatinine, bilirubin and MDA in comparison with the DC group. Contrarily, serum insulin levels, HDL-c, SOD and GSH actually were higher in the clove oil, extract and powder groups compared to the DC group. Conclusion: it could be concluded that the clove oil or extract or powder proved antioxidant qualities and has potential as a functional food ingredient to protect against the complications caused by diabetes.

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