Protective Effect of Thyme Leaves on Hepatotoxicity Compared to Silymarin in Experimental Rats

نوع المستند : مقالات علمیة محکمة

المؤلفون

1 کلية التربية النوعية جامعة المنصورة

2 قسم الاقتصاد المنزلي، کلية التربية النوعية، جامعة المنصورة، المنصورة، جمهورية مصر العربية

المستخلص

Thyme (Thymus vulgaris L.) is aromatic native herb in Mediterranean region which used extensively to add a distinctive aroma and flavor to food.Thyme possesses various beneficial effects because of pharmacological properties. This study aimed to inspect the protective effect of thyme leaves on carbon tetrachloride (CCl4) and ethanol induced liver injury in experimental rats.Twenty rats were classified into negative control group, the second group kept as positive control fed on basal diet only, silymarin group fed on basal diet contained silymarin (7.6 mg/200 g b.w) daily and thyme group fed on basal diet contained 3%thyme leaves powder instead of cellulose in diet all over the period of the experiment. After four weeks second, third and fourth groups were administered CCL4 diluted in olive oil (1:2) at dose1.5 ml/kg b.w tube and 1 ml of ethanol mixture 0.4% for three weeks by stomach then these groups consumed also 5%lard (saturated fat) at the eighth week. Carbohydrate, fiber, protein, ash, moisture and fat were found in thyme leaves. The phenolic compounds of thyme leaves in descending manner were pyrogallic, caffein, catechein, caffeic, synergic, cinnamic, chlorogenic, chrisin. protocathoic, vanillic, ferrulic, coumarin and catechol acids. There was a significant increase in nutritional parameters and silymarine and thyme groups showed significant increase in albumin and A/G ratio and antioxidant parameters and significant decrease in liver, renal function, lipid parameters in comparing with positive group. It can be recommended that the necessity of consuming thyme leaves as medicinal plant to protect the liver and prevent diseases.

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