نوع المستند : مقالات علمیة محکمة
المؤلف
Fayoum - Fayoum university - faculty of specific education
المستخلص
This study carried out to investigate the effect of different levels of red radish seeds (RRS) and celery seeds (CS) on glucocorticoid induced osteoporosis in rats. Thirty five non -pregnant female albino rats with aged 6-8 weeks, weight 170 to 200g, divided into two main groups, the first group fed on basal diet as negative control and second main group fed on basal diet injected with glucocorticoid (4mg/kg of BW) three times a week for three weeks to induce osteoporosis. Five groups were fed on basal diet containing 10%, 15% of RRS and CS and mixture of 7.5% RRS and CS for sixty days. The results of macronutrients and minerals of RRS and CS were determined; protein, fiber, carbohydrates, calcium, potassium and magnesium were high in RRS (29.16, 25.131, 35.589, 495, 396 and 316), while fat, ash, calcium, potassium and magnesium were determined in CS (5.67, 21.13, 115.93, 108.02 and 32.76). The biological results indicated increasing in body weight gain, the best results showed in the mix group (20.07 gm). Vitamin D, Ca and P increased gradually. Estradiol, Parathyroid hormone, AST, ALT, ALP, urea, creatinine, BMD, BMC and bone histological structure showed the best results in mix group, Histopathological examinations of the liver, kidneys and bones confirmed the results of the biochemical analyses. In conclusion, Red radish and celery seeds have anti osteoporotic activity in glucocorticoid induced osteoporosis, so it was recommended intake of Red radish and celery seeds for patient with osteoporosis
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