Role of pumpkin and sunflower seeds in mitigating neurotoxicity induced by some heavy metals in rats

نوع المستند : مقالات علمیة محکمة

المؤلفون

1 كلية التربية النوعية ، جامعة المنصورة، جمهورية مصر العربية

2 کلية التربية النوعية جامعة المنصورة

3 كلية التربية النوعية، جامعة المنصورة، جمهورية مصر العربية

المستخلص

The current study was aimed to investigate the therapeutic effects of pumpkin (PS.P) and sunflower (SFS.P) seeds powder against lead and cadmium-induced neurotoxicity in rats. Twenty-four male Albino rats (weight: 158 ± 3 g) were randomly allocated into four groups (6 each). The first group served as a negative control group fed only a standard diet. while 18 rats were orally gavaged with a toxic mixture of Cd (5 mg/kg b.w.) and Pb (30 mg/kg b.w.) for 30 days to induce neurotoxicity and redivided into a positive control group fed on standard diet and two treated groups with 5% from standard diet PS.P and SFS.P. The experimental duration was 60 days. Food intake and body weight were measured to assess nutritional parameters. Blood samples were collected to assays the levels of C- reactive protein (CRP), Lactic Dehydrogenase (LDH), Cyclooxygenase-2 (COX-2), Acetyl cholinesterase (AChE), Serotonin (ST), Dopamine (DA), some Lipids profile parameters, lipid peroxidation, antioxidant enzymes activity, some liver and kidney functions. The results demonstrated that groups treated with PS.P and SFS.P exhibited significant improvements in serum levels of CRP, LDH, COX-2, AChE, ST, DA, some lipids profile parameters, lipid peroxidation, antioxidant enzymes activity, and some liver and kidney functions, when compared to positive control group It can be recommended that the incorporating pumpkin and sunflower seeds into the diet due to their anti-neurotoxicity and antioxidant properties, which offer a safer therapeutic approach against lead-cadmium toxicity and help mitigate its complications especially for those exposed to lead and cadmium poisoning.

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