NUTROTHERAPEUTIC EFFECTS OF HYPERICUM PERFORATUM (HYPERICUM PERFORATUM L.) POWDER AND EXTRACT CONSUMPTION TO IMPROVE HORMONAL DISORDERS SYMPTOMS ON ELDERLY FEMALE RATS

نوع المستند : مقالات علمیة محکمة

المؤلفون

1 کلية التربية النوعية جامعة المنصورة

2 كلية التربية النوعية جامعة المنصورة

المستخلص

The current study aims to identify the effect of consuming hypericum perforatum powder and extract in improving symptoms of hormonal disorders in elderly female rats, The study was conducted on Twenty-eight female Sprague Dawley rats, classified into four  groups (7 rats each)  seven young adult female rats, three month-old and weighting 200± 15g as negative control rat group and twenty-one aged female  rats (18- 20-month-old, 300 ± 15g) were divided into three groups  positive control group fed on basal diet only , group which consumed hypericum perforatum powder (HPP)  as 15% mixed into basal diet and group  administered hypericum perforatum water extract (HPE) at a dose of 1300 mg/kg body weight daily via oral gavage. The experiment period was 60 days. The obtained Chemical results of phenolic compounds analysis of hypericum perforatum, showed that it the highest amount of e-vanillic, pyrogallol, iso-ferulic and epi-catechin their content were 1198.19, 444.11, 275.73, and 215.89 ppm respectively. The biological study showed that consumption of HPP or HPE Proved that the  significant increase in body weight gain (BWG), feed efficiency ratio (FER), serum high density lipoprotein cholesterol, (HDL-c), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone(P4)  on the other hand a significant decrease in total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) and testosterone hormone compared to positive control rat groups. It concluded that consumption of hypericum perforatum has a best treatment to improve hormonal disorders symptoms in aged menopausal female rats, should be placed within their diet plan for aged female, to protect their health from hormonal imbalances resulting from aging.

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