نوع المستند : مقالات علمیة محکمة
المؤلفون
1
كليه التربيه النوعيه جامعه المنصوره
2
کلية التربية النوعية جامعة المنصورة
المستخلص
Kidney failure is a progressive disorder linked to oxidative stress, impaired filtration, and inflammation. This study evaluated the therapeutic effects of Astragalus membranaceus (AM), in powder and aqueous extract forms, on carbon tetrachloride (CCl₄)-induced kidney dysfunction in rats. Twenty-four adult male Wistar rats (110 ± 10 g) were divided into four groups (n=6): a negative control group fed a basal diet, and three CCl₄-injected groups—positive control, AM powder-treated (5% in diet), and AM aqueous extract-treated (1:10 w/v, 7.5 mL/100 g/day for 28 days).
CCl₄ caused significant reductions in body weight, weight gain, feed intake, and feed efficiency, alongside elevated serum urea, creatinine, uric acid, ALT, AST, oxidative stress markers (MDA, H₂O₂), and CRP, with reduced antioxidant enzymes (CAT, SOD, GSH, GPx) and electrolyte imbalance.
Treatment with AM, especially in powder form, significantly improved all parameters: kidney function markers normalized, antioxidant enzyme activities increased, liver enzymes (ALT, AST) decreased, and electrolyte balance was restored. The powder form showed slightly superior effects compared to the aqueous extract.
A sensory evaluation of AM aqueous extract (5%, 10%, 15%) revealed that the 5% and 10% concentrations were most acceptable, while the 15% was less preferred due to bitterness.
In conclusion, Astragalus membranaceus—in both forms—exhibited strong protective effects against kidney dysfunction, with powdered AM showing slightly better therapeutic outcomes. It is recommended as a functional supplement for promoting kidney and liver health.
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